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Total 393357 Results
| Label | Description | ILX | Version | Created CID | Modified Time | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Amplifier | Amplifiers are used in intracellular and extracellular recording, epithelial voltage clamps, specialty instruments for micro-pressure measurement and bio-potential discrimination, and work with electrodes and transducers. | ILX:0100567 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amplitude | A physical monadic quality of occurent quality inhering in a bearer by virtue of the size of its maximum displacement from the 'normal' position, when periodic motion is taking place. | ILX:0100568 | 5 | scicrunch | 08/24/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Amprenavir | Amprenavir is a protease inhibitor used to treat HIV infection. Pharmacology: Amprenavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Amprenavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. Mechanism of action: Amprenavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. Drug type: Approved. Small Molecule. Drug category: Anti-HIV Agents. Antibiotics, Antitubercular. HIV Protease Inhibitors | ILX:0100569 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Ampulla caudalis | Caudal dilation of the spinal cord central canal. In lower vertebrates, it represents the major route by which cerebral spinal fluid enters the blood stream. | ILX:0100570 | 9 | scicrunch | 11/30/2020 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amsacrine | Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. (PubChem) Pharmacology: Amsacrine is an aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. Mechanism of action: Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum. Drug type: Approved. Small Molecule. Drug category: Antineoplastic Agents. Intercalating Agents | ILX:0100571 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amydala of WHS11 | ILX:0100572 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Amygdala | Subcortical brain region lying anterior to the hippocampal formation in the temporal lobe and anterior to the temporal horn of the lateral ventricle in some species. It is usually subdivided into several groups. Functionally, it is not considered a unitary structure (MM). | ILX:0100573 | 14 | scicrunch | 06/23/2020 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala basolateral nuclear complex nonpyramidal PV basket cell | Multipolar nonpyramidal interneuron whose axon forms multiple synaptic contacts with the somata of numerous neighboring pyramidal cells. It is one of several parvalbumin-containing interneuronal subpopulations. | ILX:0100574 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala basolateral nuclear complex nonpyramidal PV chandelier cell | Multipolar nonpyramidal interneuron whose axon forms multiple synaptic contacts with the axon initial segments of numerous neighboring pyramidal cells. It is one of several parvalbumin-containing interneuronal subpopulations. | ILX:0100575 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala basolateral nuclear complex nonpyramidal SOM neuron | Somatostatin-containing nonpyramidal neuron whose axon forms synaptic contacts with the distal dendrites and spines of neighboring pyramidal cells. Although generally considered an interneuron, at least some of these cells have distant axonal projections to the substantia innominata or entorhinal cortex. A subpopulation expresses neuropeptide Y. | ILX:0100576 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala basolateral nuclear complex pyramidal neuron | These neurons make up ~80-85% of neurons in the basolateral nuclear complex of the amygdala. Unlike cortical pyramidal cells, they are not arranged with parellel apical dendrites but are randomly organized. | ILX:0100577 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala intercalated nuclei small spiny neuron | Small spiny principal neurons of the intercalated nuclei. These nuclei are clusters of neurons surrounding rostral portions of the basolateral nuclear complex. Some of these clusters are located adjacent to the external capsule or intermediate capsule (paracapsular intercalated nuclei). | ILX:0100578 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala lateral central nucleus medium spiny neuron | Medium-sized, multipolar, principal neuron found in lateral portions of the central nucleus. It has very spiny dendrites and closely resembles the medium spiny neuron of the adjacent striatum. | ILX:0100579 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala of CIVM postnatal rat brain atlas | The amygdala is most easily segmented in the coronal plane of a diffusion-weighted image (DWI). This structure may be completely indistinguishable from surrounding regions on T2-weighted MRI. The rostral aspect of the amygdala begins as a light (low diffusivity) region just ventral to the dark (high diffusivity), ellipsoid, diagonal domain at roughly the level of the optic chiasm. Moving caudally, the lateral border of the amygdala is distinguishable from the adjacent cortex based on the dark appearance of layer 2 of the piriform cortex. The medial extent is easily identified based on the dark border created by the lateral hypothalamus and diagonal domain. The dorsal border of the amygdala with the striatum is defined by the start of the striations that define the caudate/putamen. The border with the hippocampus is equally straightforward due to the dark appearance of the alveus. The caudal border of the amygdala is a circular bulge of dark tissue on the ventral-most part of the allocortex (the posteromedial cortical amygdaloid nucleus), which emerges at around the level of the genu of the corpus callosum. | ILX:0100580 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amygdala of Macaque | ILX:0100581 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Amygdalo-entorhinal transition area of RHA11 | Cytoarchitectural field located between the ventral-intermediate entorhinal area (VIE) and the amygdalohippocampal transition area. The former is caudal and the latter is anterior to AE. Laterally, AE borders with the dorsal-intermediate entorhinal area (DIE), while medially it abuts on the periamygdaloid cortex. | ILX:0100582 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amyl Nitrite | Amyl Nitrite is an antihypertensive medicine. Amyl nitrite is employed medically to treat heart diseases such as angina and to treat cyanide poisoning. Like other alkyl nitrites, amyl nitrite is bioactive in mammals, being a vasodilator which is the basis of its use as a prescription medicine. As an inhalant, it also has psychoactive effect which has led to illegal drug use. Pharmacology: Amyl nitrite, in common with other alkyl nitrites, is a potent vasodilator. It expands blood vessels, resulting in lowering of the blood pressure. Alkyl nitrite functions as a source of nitric oxide, which signals for relaxation of the involuntary muscles. Physical effects include decrease in blood pressure, headache, flushing of the face, increased heart rate, dizziness, and relaxation of involuntary muscles, especially the blood vessel walls and the anal sphincter. There are no withdrawal symptoms. Mechanism of action: Amyl nitrite's antianginal action is thought to be the result of a reduction in systemic and pulmonary arterial pressure (afterload) and decreased cardiac output because of peripheral vasodilation, rather than coronary artery dilation. As an antidote (to cyanide poisoning), amyl nitrite promotes formation of methemoglobin, which combines with cyanide to form nontoxic cyanmethemoglobin. Drug type: Approved. Small Molecule. Drug category: Vasodilator Agents | ILX:0100583 | 5 | scicrunch | 08/24/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | troy sincomb |
| Amylin | ILX:0100584 | 3 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex | |
| Amyloid Aggregate | Insoluble fibrous protein aggregation sharing specific structural traits. | ILX:0100585 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
| Amyloid Fibril | A fibril composed of amyloid protein. | ILX:0100586 | 4 | scicrunch | 06/18/2018 | scicrunch | term | 12/08/2016 | 0 | NeuroLex | NeuroLex |
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